Úvod Laboratorní plasty Zkumavky Microcentrifuge Tube 1.5 ml Microcentrifuge Tube SALSA MLPA P014 Chromosome 8 probemix - 100 reactions

SALSA MLPA P014 Chromosome 8 probemix - 100 reactions

SALSA MLPA P014 Chromosome 8 probemix - 100 reactions

application: Tumour research
region: Chromosome 8
  Detailní informace

Cena s DPH 32 670 Kč
Cena bez DPH 27 000 Kč
 100 react
Dostupnost Skladem
Kód produktu P014-100R

Nejnovější informace o produktu naleznete exklusivně na stránkách výrobce MRC-Holland www.mlpa.com (nové okno)

Detailní popis SALSA MLPA P014 Chromosome 8 probemix - 100 reactions

P014-100R SALSA MLPA P014 Chromosome 8 probemix – 100 rxn

Copy number changes of the human chromosome 8 are common in many types of tumours. In most cases, losses of 8p sequences and gains of 8q sequences are detected. This probemix is designed to have probes evenly spread over chromosome 8 and contain probes for tumour suppressors (e.g. MTUS, LZTS1), DNA damage response genes (e.g. MCPH1) and cell cycle genes (e.g. MYC). For a complete list of chromosome 8 probes in this product, see table 2a.

This probemix contains 44 probes for different genes on chromosome 8  that are suggested to be involved in human tumours. In addition, 12 reference probes have been included in this probemix, detecting 12 different autosomal chromosomal locations, which are relatively silent in most tumour types. However, it should be noticed that tumour karyotypes can harbour multiple numerical and structural aberrations, which can complicate interpretation of these reference probes.

This SALSA® MLPA® probemix is designed to detect deletions/duplications of one or more sequences in the above mentioned chromosomal regions in a DNA sample. Heterozygous deletions of recognition sequences should give a 35-50% reduced relative peak height of the amplification product of that probe. Note that a mutation or polymorphism in the sequence detected by a probe can also cause a  reduction in relative peak height, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplications detected by MLPA should always be confirmed by other methods. Not all deletions and duplications detected by MLPA will be pathogenic; users should always verify the latest scientific literature when interpreting their findings. We have no information on what percentage of defects in these genes is caused by deletions/duplications of complete exons. Finally, note that most defects in these genes are expected to be small (point) mutations, which will not be detected by this SALSA® MLPA® test.

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