SALSA MLPA P157 20q probemix - 50 reactions

SALSA MLPA P157 20q probemix - 50 reactions

application: Colon cancer, breast cancer and various others
region: 20q (BCL2L1, MYBL2, ZNF217, DNMT3B, AURKA, GNAS) Detailní informace

Cena s DPH € 588.06
Cena bez DPH € 486.00
 50 react
Dostupnost Skladem
Kód produktu P157-050R

Nejnovější informace o produktu naleznete exklusivně na stránkách výrobce MRC-Holland (nové okno)

Detailní popis SALSA MLPA P157 20q probemix - 50 reactions

P157-050R SALSA MLPA P157 20q region probemix – 50 rxn

Copy number changes in the chromosome 20q region are very common in several types of cancer, including colon cancer. Among the interesting genes on 20q are: BCL2L1, AURKA, DNMT3B, SRC, MYBL2, PTPN1, ZNF217, BCAS1 and GNAS.

This P157 20q region probemix contains 34 probes for 26 different genes located on 20q, as well as five probes specific for 20p sequences. In addition, 14 reference probes are included in this probemix detecting sequences on other chromosome arms, predominantly “quiet” regions in colon cancer.

This SALSA® MLPA® probemix is designed to detect deletions/duplications in the 20q region in a DNA sample. Heterozygous deletions of probe recognition sequences should give a 35-50% reduced relative peak area of the amplification product of that probe. Note that a mutation or polymorphism in the sequence detected by a probe can also cause a reduction in relative peak area, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplications detected by MLPA should always be confirmed by other methods. Not all deletions and duplications detected by MLPA will be pathogenic; users should always verify the latest scientific literature when interpreting their findings. We have no information on what percentage of defects in these genes is caused by deletions/duplications of complete exons. Finally, note that most defects in this gene are expected to be small (point) mutations which will not be detected by this SALSA® MLPA® test.

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