Úvod Laboratorní plasty Zkumavky Microcentrifuge Tube 1.5 ml Microcentrifuge Tube SALSA MLPA P301 Medulloblastoma mix 1 probemix - 34 reactions

SALSA MLPA P301 Medulloblastoma mix 1 probemix - 34 reactions

SALSA MLPA P301 Medulloblastoma mix 1 probemix - 34 reactions


region: Chr. 6, Chr. 14, Chr. 16, Chr. 17 Detailní informace

Cena s DPH € 382.36
Cena bez DPH € 316.00
 34 react
Dostupnost Skladem
Kód produktu P301-034R

Nejnovější informace o produktu naleznete exklusivně na stránkách výrobce MRC-Holland www.mlpa.com (nové okno)

Detailní popis SALSA MLPA P301 Medulloblastoma mix 1 probemix - 34 reactions

P301-025R SALSA MLPA P301 Medulloblastoma mix 1 probemix – 50 rxn

Medulloblastoma is the most common pediatric primary central nervous system tumour and accounts for between 15% and 20% of central nervous system tumours in patients under the age of 20. It is a highly invasive embryonal neuroepithelial tumour that arises in the cerebellum and has a tendency to disseminate throughout the CNS early in its course. Overall survival is between 50%-60% at 5 years, although this decreases to 30% in the longer term due to local recurrence or metastasis. Common symptoms are unsteadiness, headaches and vomiting.

The P301-A2 probemix contains probes for chromosomes 6, 14q, 16 and 17, the P302-A2 probemix for chromosomes 2, 3, 7 and 9, and the P303-A2 for chromosomes 1, 4q, 5q, 8, 10 and 20. In addition, at least 10 reference probes are included in every mix.

This SALSA® MLPA® probemix is designed to detect deletions/duplications of one or more sequences in the above mentioned chromosomal regions in a DNA sample. Heterozygous deletions of recognition sequences should give a 35-50% reduced relative peak area of the amplification product of that probe. Note that a mutation or polymorphism in the sequence detected by a probe can also cause a reduction in relative peak area, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplications detected by MLPA should always be confirmed by other methods. Not all deletions and duplications detected by MLPA will be pathogenic; users should always verify the latest scientific literature when interpreting their findings. Finally, note that most defects in this gene are expected to be small (point) mutations which will not be detected by this SALSA® MLPA® test.

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