Úvod Laboratorní plasty Zkumavky Microcentrifuge Tube 1.5 ml Microcentrifuge Tube SALSA MLPA P373 Microdeletion-7 probemix - 100 reactions

SALSA MLPA P373 Microdeletion-7 probemix - 100 reactions

Microdeletion follow-up, Chat, Phelan-McDermid. Detailní informace

Cena s DPH € 1 147.08
Cena bez DPH € 948.00
 100 react
Dostupnost Skladem
Kód produktu P373-100R

Nejnovější informace o produktu naleznete exklusivně na stránkách výrobce MRC-Holland www.mlpa.com (nové okno)

Detailní popis SALSA MLPA P373 Microdeletion-7 probemix - 100 reactions

P373-025R SALSA MLPA P373 Microdeletion syndromes 7 probemix – 100 rxn

description
The purpose of the P373 probemix is to further investigate results found with the P245 Microdeletion probemix. The P245-A version probemix provides a possibility to screen samples for 21 different microdeletion syndromes in a single reaction. For confirmation of results obtained with this P245 probemix, four different probemixes are now available with additional probes in these 21 regions: P371, P372, P373 and P374 Microdeletion syndromes.

The P373-B1 probemix contains probes for the 1p36 region (13 probes), the 3q29 Microdeletion syndrome region (8 probes), the Wolf-Hirschhorn region on 4p (8 probes), the Cri-du-chat region on 5p (12 probes), and the 22q13 Phelan-McDermid region (8 probes).

This SALSA® MLPA® probemix is designed to detect deletions/duplications of one or more sequences in the aforementioned regions in a DNA sample. Heterozygous deletions of recognition sequences should give a 35-50% reduced relative peak area of the amplification product of that probe. Note that a mutation or polymorphism in the sequence detected by a probe can also cause a reduction in relative peak area, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplications detected by MLPA should always be confirmed by other methods. Not all deletions and duplications detected by MLPA will be pathogenic; users should always verify the latest scientific literature when interpreting their findings. We have no information on what percentage of defects in these genes is caused by deletions/duplications of complete exons. Finally, note that most defects in this gene are expected to be small (point) mutations which will not be detected by this SALSA® MLPA® test.

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